Live HIV vaccines — How safe?

New opportunities for development of safe, effective live virus vaccines.

Effective vaccines are not available for most viral diseases. This situation may soon change when the full force of contemporary molecular biology is applied to immunoprophylaxis. In certain viral diseases, particularly those affecting the respiratory and gastrointestinal tracts, live attenuated vaccines are needed to confer effective protection. Until now the major obstacle to success has been...

A comparative study of two live measles vaccines in Iran

How safe is safe enough?

Hospitals are rather strange places to work. The rationale, after all, of purposely concentrating into close quarters the sick, the frail, and the contagious is elusive at times. Further compounding the situation is the introduction of healthcare workers into the mix, usually at the ratio of approximately five or six full-time employees for every hospital bed. In no other circumstance, except p...

Safer Conception Strategies for HIV-Serodiscordant Couples: How Safe Is Safe Enough?

With access to antiretroviral therapy (ART), human immunodeficiency virus (HIV)–infected men and women are living longer and healthier lives and have childbearing desires similar to those of HIV-unaffected individuals [1]. Many are in HIV-serodiscordant sexual partnerships (with an HIV-uninfected partner), and attempts at conception confer sexual HIV transmission risk [2]. HIV risk reduction st...

Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe?

We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective reporting of results from clinical trials (i.e., exclusion of vaccine efficacy...